Like trastuzumab, pertuzumab is a monoclonal antibody that attaches to the HER2 protein. It seems to target a different part of the protein than trastuzumab does. This drug can be used along with docetaxel (Taxotere) and trastuzumab to treat patients with advanced breast cancer. This 3 drug combination can also be used to treat earlier-stage breast cancers before surgery (as neoadjuvant therapy).

This drug is given as an infusion into a vein every 3 weeks.

Side Effects:

When given with trastuzumab and docetaxel, common side effects included

  • diarrhea
  • hair loss
  • nausea
  • fatigue
  • rash
  • low white blood cell counts (sometimes with fever)

Many side effects, such as hair loss, nausea, and fatigue occur at about the same rate as in those who get just docetaxel and trastuzumab.


Risk Factor

Like trastuzumab, pertuzumab can weaken the heart and cannot be taken if you already have poor heart function. Your doctor will check tests of heart function before starting this drug and again every few months during treatment with pertuzumab.




Bone-directed therapy for breast cancer in men


Coping and support for male breast cancer


Related Topics

Benign breast conditions

General breast cancer terms

Types of breast cancer in men







Oncologists, Breast Surgeons are the specialists who deal with the breast cancer