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Everolimus-Afinitor

Everolimus is a pill taken once a day to block mTOR, a protein in cells that normally promotes their growth and division. By blocking this protein, everolimus can help stop cancer cells from growing. Everolimus may also stop tumors from developing new blood vessels, which can help limit their growth. In treating breast cancer, this drug seems to help hormone therapy drugs work better.

This drug is approved to treat advanced hormone receptor-positive, HER2-negative, breast cancer in women who have gone through menopause. It is meant to be used with exemestane (Aromasin) in these women if their cancers have grown while they were being treated with either letrozole or anastrazole (or the cancer started growing shortly after stopping treatment with these drugs). It has also been studied for use with other hormone therapy drugs. It may help hormone drugs work better in men who have hormone-receptor positive breast cancer, but this has not been studied.

Everolimus is also being studied for use for earlier stage breast cancer and combined with other treatments. Although most of the people with breast cancer in studies of everolimus are women, some studies have included men.

Side Effects

Common side effects of this drug include

  • mouth sores
  • diarrhea
  • nausea
  • fatigue
  • feeling weak or tired
  • low blood counts
  • shortness of breath
  • cough

 

Risk Factor

Everolimus can also increase blood lipids (cholesterol and triglycerides) and blood sugars, so your doctor will check your blood work periodically while you are on this drug. It can also increase your risk of serious infections, so your doctor will watch you closely for infection while you are on treatment.

 

 

Bone-directed therapy for breast cancer in men


 

Coping and support for male breast cancer

 


Related Topics

Benign breast conditions

General breast cancer terms

Types of breast cancer in men


References

http://www.cancer.org/cancer/breastcancerinmen/detailedguide/breast-cancer-in-men-what-is-breast-cancer-in-men

http://www.breastcancer.org/symptoms/types/male_bc

http://www.cancerresearchuk.org/about-cancer/type/rare-cancers/rare-cancers-name/breast-cancer-in-men

http://www.mayoclinic.org/diseases-conditions/male-breast-cancer/basics/coping-support/con-20025972


 

Oncologists, Breast Surgeons are the specialists who deal with the breast cancer

 

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