Hormone therapy for Male Breast Cancer

Hormone therapy is the use of hormones or drugs or other treatments that affect hormones in treating cancer. Hormone therapy is another form of systemic therapy. Like chemotherapy, hormone therapy can be used as an adjuvant therapy to help reduce the risk of cancer recurrence after surgery, or as neoadjuvant treatment. It is also used to treat cancer that has come back after treatment (recurred) or has spread.

Some breast cancers grow in response to the hormone estrogen. Estrogen is usually thought of as a female hormone, but men have it in their bodies as well, just at lower levels. About 9 of 10 breast cancers in men are hormone receptor-positive (either estrogen receptor (ER)-positive and/or progesterone receptor (PR)-positive). This makes them more likely to respond to hormone treatments. Hormone therapy does not help people whose tumors are both ER- and PR-negative.

Several approaches to blocking the effects of estrogen or lowering estrogen levels are used to treat breast cancer in women. Although many of these may work in men as well, they often haven’t been studied well, if at all. The anti-estrogen drug, tamoxifen, is the best studied hormone drug for breast cancer in men and is most often used first. If tamoxifen doesn’t work (or stops working), other hormone drugs may be tried, but this is largely based on how well they work in women with breast cancer.

Tamoxifen and Toremifene-Fareston

Aromatase inhibitors


Luteinizing hormone-releasing hormone-LHRH analogs and anti-androgens



Possible side effects of hormone therapy



Targeted therapy for breast cancer in men

Bone-directed therapy for breast cancer in men

Coping and support

Related Topics

Benign breast conditions

General breast cancer terms

Types of breast cancer in men







Oncologists, Breast Surgeons are the specialists who deal with the breast cancer