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Aromatase inhibitors

This group of drugs includes anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin). They work by blocking an enzyme (aromatase) in fat tissue that converts male hormones from the adrenal glands into estrogen. Aromatase inhibitors are taken daily as pills. They have been very effective in treating breast cancer in women, but they have not been well-studied in men. Still, some doctors use them to treat advanced breast cancer in men, often combined with a luteinizing releasing hormone analog to turn off hormone production by the testicles.

These drugs are generally used if tamoxifen stops working. They are also sometimes used as the first line of hormone therapy instead of tamoxifen, but this has been linked to poorer outcomes. The main side effects of these drugs are thinning of the bones and joint and muscle pain.

Fulvestrant-Faslodex

Luteinizing hormone-releasing hormone-LHRH analogs and anti-androgens

Megestrol

Orchiectomy-castration

Possible side effects of hormone therapy

 


Targeted therapy for breast cancer in men

Bone-directed therapy for breast cancer in men


 

Coping and support for male breast cancer

 


Related Topics

Benign breast conditions

General breast cancer terms

Types of breast cancer in men


References

http://www.cancer.org/cancer/breastcancerinmen/detailedguide/breast-cancer-in-men-what-is-breast-cancer-in-men

http://www.breastcancer.org/symptoms/types/male_bc

http://www.cancerresearchuk.org/about-cancer/type/rare-cancers/rare-cancers-name/breast-cancer-in-men

http://www.mayoclinic.org/diseases-conditions/male-breast-cancer/basics/coping-support/con-20025972


 

Oncologists, Breast Surgeons are the specialists who deal with the breast cancer

 

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