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Maturity onset diabetes of the young-MODY

MODY is a monogenic form of diabetes that usually first occurs during adolescence or early adulthood. However, MODY sometimes remains undiagnosed until later in life. MODY is a rare form of diabetes which is different from both Type 1 and Type 2 diabetes, and runs strongly in families. MODY is caused by a mutation (or change) in a single gene. If a parent has this gene mutation, any child they have, has a 50% chance of inheriting it from them.

People with MODY may have only mild or no symptoms of diabetes and their hyperglycemia may only be discovered during routine blood tests. MODY may be confused with type 1 or type 2 diabetes. People with MODY are generally not overweight and do not have other risk factors for type 2 diabetes, such as high blood pressure or abnormal blood fat levels. While both type 2 diabetes and MODY can run in families, people with MODY typically have a family history of diabetes in multiple successive generations, meaning that MODY is present in a grandparent, a parent, and a child. Unlike people with type 1 diabetes who always require insulin, people with MODY can often be treated with oral diabetes medications.

If a child does inherit the mutation they will generally go on to develop MODY before they’re 25, whatever their weight, lifestyle, ethnic group etc.

The key features of MODY

The most common types of MODY

Important information if you have MODY

Testing for MODY

 

 

More Topics

Type 1 Diabetes Alström Syndrome
Type 2 Diabetes Neonatal diabetes
Wolfram Syndrome Preventing complications of Diabetes

References

https://www.diabetes.org.uk/Guide-to-diabetes/What-is-diabetes/Other-types-of-diabetes/MODY/

https://www.niddk.nih.gov/health-information/diabetes/types/monogenic-neonatal-mellitus-mody

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